Sialic acid-tastic in 2015

We are pleased to announce that two of our papers with valued collaborators on two aspects of sialic acid biology in Tannerella were published in autumn 2015.

Phansopa et al, describes characterisation of a novel SGNH hydrolase that cleaves acetyl-groups from di-acetylated sialic acids (Neu5,9 and Neu5,4) to allow access of sialidases.  This was a collaborative effort with the team from Ludger Ltd and should precede other big news on this collaboration.

Honma et al., describes the import of NanT sialic acid transporter in sialic acid uptake and intracellular survival in human cells and is the latest in a line of papers with Ashu Sharma from SUNY-at Buffalo.

Specifically:

Phansopa C, Kozak RP, Liew LP, Frey AM, Farmilo T, Parker JL, Kelly DJ, Emery RJ, Thomson RL, Royle L, Gardner RA, Spencer DI, Stafford GP (2015) Characterization of a sialate O-acetyl esterase (NanS) from the oral pathogen Tannerella forsythia that enhances sialic acid release by NanH its cognate sialidase. Biochem J. 2015 Sep 16. pii: BJ20150388

Honma K, Ruscitto A, Frey AM, Stafford GP, Sharma A. (2015) Sialic acid transporter NanT participates in Tannerella forsythia biofilm formation and survival on epithelial cells. Microb Pathog. 2015 Aug 28. pii: S0882-4010(15)00143-6. doi: 10.1016/j.micpath.2015.08.012.