Dr Matthew Hicks

Matt left the team in 2013 but has had a successful time since:

He is currently a bid support manager at the University of Derby after previously working as a

Research Proposal Writer at Pera Technology.

http://uk.linkedin.com/pub/matthew-hicks/17/17b/502

Previous Career History

1997-2001: University of Liverpool BSc (Hons) Applied Biochemistry.

1999-2000: “Praktikum”- extra mural industrial placement, Biotechnology Research, BTFF, Lonza AG, Visp, Switzerland

2001-2004: John Innes Centre Ph.D. Function of Tat subunits in Escherichia coli (Prof. Tracy Palmer, examined by Prof. Ian Booth, Aberdeen)

2004- 2007: University of East Anglia, Post- Doctoral Research Associate. Mechanisms of outer membrane biogenesis in E. coli

2007-2010: University of East Anglia, Senior Post Doctoral Research Associate. Lipoprotein biogenesis in Streptomyces

2012-Present: University of Sheffield, Post-Doctoral Research Associate.

Current Research

Dr Matthew Hicks

 


I am currently working on a BBSRC funded project entitled; Use of Synthetic Biology in the Development of Bacterial Adhesins for Skin Grafting applications. This proposal grew from the MATEs synthetic biology network and will focus on the use of bacterial protein fibres to present adhesive peptides to aid the adhesion of human skin cells with future applications in the improvement of skin grafting and tissue engineering.

I joined the University of Sheffield in 2012 after postdoctoral positions and a PhD at UEA in Norwich examining outer membrane biogenesis and lipoproteins in Streptomyces and before that a BSc in Liverpool.

I am a member of the following learned societies

Society for General Microbiology

Publications

Widdick, D. A., Hicks, M. G., Thompson, B. J., Tschumi, A., Chandra, G., Sutcliffe, I. C., Brülle, J. K., Sander, P., Palmer, T., Hutchings, M. I. (2011) Dissecting the complete lipoprotein biogenesis pathway in Streptomyces scabies. Mol. Microbiol. 80: 1395-412. (Joint First Authorship, one citation)

Thompson, B. J., Widdick, D. A., Hicks, M. G., Chandra, G., Sutcliffe, I. C., Palmer, T. and Hutchings, M. I. (2010) Investigating lipoprotein biogenesis and function in the model Gram-positive bacterium Streptomyces coelicolor . Mol. Microbiol. 77: 943-956.

Andrell, J., Hicks M. G., Palmer, T., Carpenter, E. P., Iwata, S., Maher, M. J. (2009) Crystal structure of the acid-induced arginine decarboxylase from Escherichia coli: reversible decamer assembly controls enzyme activity. Biochemistry. 48: 3915-3927. (Five citations)

Tucker, N. P., Hicks, M. G., Clarke, T. A., Crack, J. C., Chandra, G., Le Brun, N. E., Dixon, R., Hutchings, M. I. (2008) The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster. PLoS One. 3: e3623. (Six citations)

Donald, J. W., Hicks, M. G., Richardson, D. J., Palmer, T. (2008) The c-type cytochrome OmcA localizes to the outer membrane upon heterologous expression in Escherichia coli. J. Bacteriol. 190: 5127-5131. (Three citations)

Greene, N. P., Porcelli, I., Buchanan, G., Hicks, M. G., Schermann, S.M., Palmer, T., Berks, B.C. (2007) Cysteine scanning mutagenesis and disulfide mapping studies of the TatA component of the bacterial twin arginine translocase. J. Biol. Chem. 282: 23937-2945. (Seven citations)

Pérez-Rodríguez, R., Fisher, A.C., Perlmutter, J.D., Hicks, M.G., Chanal, A., Santini, C.-L., Wu, L.-F., Palmer, T, DeLisa, M.P. (2007). An essential role for the DnaK molecular chaperone in stabilizing over-expressed substrate proteins of the bacterial twin-arginine translocation pathway. J. Mol. Biol. 367: 715-730. (14 citations)

Hicks, M.G., Guymer, D., Buchanan, G., Widdick, D.A., Caldelari, I., Berks, B.C., Palmer, T. (2006) Formation of functional Tat translocases from heterologous components. BMC Microbiol. 6: 64. (One citation)

Hicks, M.G., Lee, P. A., Georgiou, G., Berks, B. C., Palmer, T. (2005) Positive selection for loss-of-function tat mutations identifies critical residues required for TatA activity. J. Bacteriol. 187: 2920-2925. (Three citations)

McDevitt, C. A., Hicks, M. G., Palmer, T., Berks, B. C. (2005) Characterisation of Tat protein transport complexes carrying inactivating mutations. Biochem Biophys Res Commun. 329: 693-698. (Five citations)

Hicks, M. G., de Leeuw, E., Porcelli, I., Buchanan, G., Berks, B. C., Palmer. T. (2003) The Escherichia coli twin-arginine translocase: conserved residues of TatA and TatB family components involved in protein transport. FEBS Lett. 539: 61-67. (Six citations)