Dr Chatchawal Phansopa

Chat has moved to the dept of Animal of Plant Sciences Sheffield as a PDRA

 

Career History

2003 – 2006 B.Sc. (Hons) Microbiology

Department of Molecular Biology and Biotechnology, University of Sheffield

 

2006 – 2011 Ph.D.

Department of Molecular Biology and Biotechnology, University of Sheffield

 

2011 – Present Postdoctoral Research Fellow

School of Clinical Dentistry, University of Sheffield

 

Research Interests

My Ph.D. project was carried out under the supervision of Professor David J. Kelly at the University of Sheffield. The focus of this study was on the structural, biochemical and physiological characterisation of a group of antigenic proteins (PEB4, Cj1289 and Cj0694) of the food-borne pathogen Campylobacter jejuni. Apart from being cell-surface adhesins, we have demonstrated that these proteins also accelerated in vitro protein folding and/or peptidyl-prolyl cis/trans isomerisation. Together, they may form a network of chaperones responsible for the maturation of β-barrel outer membrane proteins during secretion. I am currently investigating the roles of several sialic acid utilisation proteins in the oral pathogen Tannerella forsythia and investigate the general relationship of this sugar with human pathogens. This project was funded by a Dunhill Medical Trust Research (DMT) Grant to Dr Graham Stafford and Professor Ian Douglas.

 

Contact Details

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+44 (0)114 271 7965

 

I am a member of the Society for General Microbiology.

 

Publications

Phansopa, C., Roy, S., Rafferty, J. B., Douglas, C. W. I., Pandhal, J., Wright, P. C., Kelly, D. J. and Stafford, G. P. (2013)  Structural and functional characterisation of NanU, a novel high-affinity sialic acid-inducible binding protein of oral and gut-dwelling Bacteroidetes spp. Biochem. J. e pub ahead of print

Settem, RP, Honma, K, Nakajima, T, Phansopa, C, Roy,S, Stafford, GP and Ashu Sharma (2012) A bacterial glycan core linked to surface (S)-layer proteins modulates host immunity through Th17 suppression Mucosal ImmunologyIn Press.

Roy, S; Phansopa, C.; Stafford, P.; Honma, K.; Douglas, I.; Sharma, A. and Stafford G.P. (2012) Beta-hexosaminidase activity of the oral pathogen Tannerella forsythia influences biofilm formation on glycoprotein substrates FEMS Immun & Med Micro, 65(1):116-20

Kale, A., Phansopa, C., Suwannachart, C., Craven, C. J., Rafferty, J. B. and Kelly, D. J.The virulence factor PEB4 (Cj0596) and the periplasmic protein Cj1289 are two structurally related SurA-like chaperones in the human pathogen Campylobacter jejuni. J. Biol. Chem. 2011;286(24):21254–65.