Graham Stafford Research Group overview
The research group is housed in the School of Clinical Dentistry at the University of Sheffield. The group is part of a larger research effort in the department known as the Integrated Bioscience grouping which is lead by Graham Stafford and encompasses a range of research activities. The iBio group includes several valued collaborators (particularly Professor Ian Douglas and Dr Dan Lambert) while we also actively collaborate with other researchers from around the University of Sheffield and the world.
Research in the Dental School is conducted in shared space in research laboratories which contain state-of-the-art Cell culture, Molecular Biology and Microbiology facilities. These contain facilities for Real-time PCR, Epifluorescence microscopy, luminometry, HPLC, fermentation, Anaerobic culture, protein purification as well as more standard equipment.
The Group is growing and is made up of a mixture of Postdocs, PhD students and various MSc, undergraduate and BMedSci students who work on short term projects with us regularly and is comprised of several nationalities.
The work within the group is centred around the use of molecular and biochemical techniques to elucidate the virulence mechanisms employed by human pathogens with a focus on interaction with human cells, biofilm, sialic acid, glycans and protein assembly/secretion. We also have a strong focus on applying knowledge of bacterial protein secretion systems for biomedical applications using a synthetic biology approach with colleagues in Chemical and Biological Engineering.
We collaborate and work with commerical partners wherever possible and currently have fruitful links with Ludger Ltd, GSK, Blueberry Therapeutics and Fujifilm Diosynth Biotechnogies.
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